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A Brief Review Of Dosage: A Practical Approachby Steven A. Roman, Ph.D.Dosage, a technique for classifying Thoroughbred pedigrees by type based on aptitudinal characteristics inherited from selected sires, originated in the early part of this century from the research of the Frenchman Lt. Col. J. J. Vuillier. In his classic study of the extended pedigrees of the best runners in England and France, Vuillier (in LES CROISEMENTS RATIONNELS DANS LA RACE PURE) observed that very few stallions appeared with any great frequency. He called these stallions "chefs-de-race". He also noted that the degree of inheritance attributed to each of these "chefs" was essentially constant in all pedigrees, the absolute value (or Dosage figure) varying from sire to sire. Furthermore, he demonstrated that in successive 15 to 20 year time frames, new series of "chefs" emerged which eventually established their own fixed degree of influence. This process, in which new series of "chefs" periodically become dominant, provides a rational model for the evolution of the Thoroughbred race horse. Vuillier believed that the objective in breeding should be to attain Dosage figures in the foal as close as possible to the established Dosage figures for the breed. For some time, he practiced his theories successfully in the employ of H. H. The Aga Khan, breeder of such notables as Bahram, Majideh, Mahmoud and Nasrullah, among many others. Some years later, the Italian Dr. Franco Varola (in TYPOLOGY OF THE RACE HORSE) developed a modified version of dosage that retained the principle that Thoroughbred evolution proceeds through the influence of a very small number of the stallions at stud in any era. Varola did, however, shift the emphasis from quantity (i.e., the degree of inheritance associated with individual sires) to quality (i.e., the pattern of aptitudinal traits inherited from key ancestors). Discounting the generation in which his expanded list of "chefs" appeared, he arrived at a distribution of aptitudinal traits in a given pedigree that described the "type" of the horse being analyzed. A significant point made by Varola was that the characteristics transmitted by his "chefs" were not necessarily those they possessed as runners. The focus, instead, was entirely on the qualities passed on as breeding animals. Thus, in contrast to conventional pedigree analysis based on a historical perspective of ancestral performance, Dosage relies on the dynamics of inheritance. As an alternative and complementary method of pedigree interpretation, it may help avoid potential problems associated with the traditional concept of "breeding the best to the best". Our approach, which first appeared publicly as a series of articles in Leon Rasmussen's Bloodlines column in Daily Racing Form just prior to the 1981 Kentucky Derby, has been to fuse the basic ideas of Vuillier and Varola, incorporating both quantitative and qualitative components in the hope of providing additional insights. In order to establish greater utility, we chose to use more accessible four-generation pedigrees instead of the extended pedigrees used previously. We also introduced an approximation of a genetic effect by halving the influence of any "chef" in each successive earlier generation. Finally, we established a statistical method for evaluating the results of our analysis. In this framework, Dosage in its latest configuration was developed. "Chefs", chosen on the basis of their observable prepotence for type, are assigned to one or two of five aptitudinal groups (Brilliant, Intermediate, Classic, Solid, and Professional) covering the spectrum (from left to right) of speed to endurance. The assignments are made to best reflect the traits that these stallions predictably and consistently transmit to their offspring. For bookkeeping purposes we assign a total potential value of 16 points to each generation. Since there are, progressively, one, two, four, and eight sires in the first four generations, "chefs" that appear among these sires will contribute 16, 8, 4, and 2 points to each as we work back. The points for all "chefs" present are then tallied in the appropriate aptitude columns. "Chefs" that confer two aptitudinal characteristics have their points split between the two aptitudes. In the end, the total points in each column produce the Dosage Profile (DP), a series of five numbers that reflects the relative proportions of each of the five aptitudes and is expressed in the order: Brilliant-Intermediate-Classic-Solid-Professional For example, the DP for Sea Hero (Polish Navy-Glowing Tribute, by Graustark) is 3 - 5 - 22 - 4 - 2. The ratio of points in the speed wing (Brilliant points + Intermediate points + one-half the Classic points) to points in the stamina wing (one-half the Classic points + Solid points + Professional points) is the Dosage Index (DI). This number is directly proportional to the inherited prepotent speed in a pedigree and inversely proportional to the stamina. A DI of 1.00 indicates a perfect balance of the two. The DI of Sea Hero is 1.12 ((3 + 5 + 11) divided by (11 + 4 + 2)). If we consider the five aptitude groups as points spaced equally along a linear scale where Brilliant is assigned a value of +2.00, Intermediate is +1.00, Classic is 0.00, Solid is -1.00, and Professional is -2.00, the DP allows for the calculation of the Center of Distribution (CD), that point along the scale corresponding to the total combined influences of all "chefs" in the pedigree. In that sense, it is a balance point (analogous to a center of gravity) of all weighted aptitudes supplied by "chefs" in the four generations. Calculation of the CD is done by taking the sum of twice the Brilliant points plus Intermediate points minus Solid points minus twice the Professional points and dividing that number by the total points in the DP. An exact balance of speed and stamina yields a CD of 0.00. The CD for Sea Hero is 0.08 (((2 x 3) + 5 - 4 -(2 x 2)) divided by (3 + 5 + 22 + 4 + 2)), which places the combined effect of all "chefs" in his four generation pedigree between the Classic and Intermediate aptitudes, although closer to the Classic. Research using the described methodology as a tool for pedigree classification has resulted in a number of revealing observations including the following:
The studies discussed here are based on large populations that reflect statistically significant trends within the total gene pool; therefore, when applying the methodology to individual horses, we must consider the probability that the individual will perform according to expectations. A higher degree of accuracy, as well as an associated predictability, will depend in large part on a continual modification and refinement of the chef-de-race list, guided by the principle of a better description of reality. |